Prognostic Effect Of Rectal Cancer - 1017 Words

A report from American cancer society declared that reliable statistics on deaths from colon and rectal cancers separately are not available due to almost 40% of deaths from rectal cancer being misclassified as colon cancer on death certificates.2. Therefore, this systematic review and meta-analysis on prognostic specific miRNA expression in CRC is a crucial step in highlighting patient clinical outcome patterns which will inform clinical decision makers on CRC treatment and administration with regards to deregulated miRNA expression. Data for why stage 2 must be added METHODS This study aims to evaluate the prognostic effect of miRNA expression in stage II CRC patients. The research protocol follows the PRISMA-P (the Preferred Reporting†¦show more content†¦Google Scholar, though not a bibliographic database, will be used to improve the quality of the search results. Research lists of articles passing the initial screening process will also be used as auxiliary sources to improve the search strategy. Published research theses may also be used as viable data sources if novel or critical findings in regards to CRC and miRNA expression are reported. Study selection Primary screening will be based on the relevance of paper to the topic of the study. The screening will be performed individually by two authors blinded to each other’s results of selection, upon cursory examination of abstracts and titles of selected articles. All articles deemed to be suitable by either author will be included for further selection. The final selection will be based on the defined inclusion and exclusion criteria. The discrepancies that arise will be dealt with by deliberation and debate between the two authors. A third reviewer will be involved during this process to act as the final tie-breaker vote in case of the discussion arriving at a standstill. A diagrammatic representation detailing the selection process will be a part of the final systematic review and meta-analysis. Data extraction and management A standardised, Microsoft Excel mastersheet framework will be developed to record data extractedShow MoreRelatedSystematic Review Paper981 Words   |  4 Pagesdetection and treatment of colorectal cancer has seen marked improvements in recent years. However, it is still the third leading cause of cancer related death worldwide. Although there are studies reporting the significance of miRNAs in stage II colorectal cancer, there is, as of yet, no known comprehensive study utilizing collective data from multiple published studies. It is imperative that this knowledge gap of viable miRNA biomarkers in stage II colorectal cancer, be filled. Thus, this study willRead MoreThe Mantle Cell Lymphoma ( Mcl )1697 Words   |  7 Pageslymphoma are cancers that do not originate in white blood cells but rather elsewhere in the lymphatic system such as a lymph node, bone marrow, spleen, or thymus and are categorized into which cells it effects such as B-cell, T-cell and NK-cells (MD Cancer Center , 2015). B-cell lymphoma represents the majority of non-Hodgkin Lymphoma (85%) and of these Mantle Cell Lymphoma (MCL) represents about 5% of the type of B-cell lymphoma (American Cancer Society, 2015). According to the American Cancer SocietyRead MoreCase Study On BMI Levels1009 Words   |  5 Pagesdevelopment of various malignant diseases, including colorectal cancer, breast cancer and PC [7]. Conversely, the relationship between PC and obesity is still a matter of debate [8]. The findings reported in the present study that provide better prognosis were associated with BMI 25 kg/m2. In the multivariate analysis, serum AKP levels, serum albumin levels, visceral metastasis, and BMI 25 kg/m2 were reported as significant prognostic factors with cumulative survival probability in 10, 20 and 30Read MoreErc1 Lab Report1848 Words   |  8 Pageswhether MGMT and ERCC1 DNA methylation is diagnostic of human cancer rectum, we detected the frequency of MGMT and ERCC1 methylation in 50 serious of primary cancer rectum samples and 43 benign rectum tumors by MSP. MGMT and ERCC1 were methylated for 13.9% and 18.6% in the benign tissue and for 4.7% and 7% in the blood, respectively. On the contrary, a methylation-positive pattern of MGMT and ERCC1 was observed for 80% and 74% of cancer rectum tissues and for 58% and 60% of the blood, respectivelyRead MoreProper Prostrate Cancer Treatment Essay2063 Words   |  9 PagesBeing diagnosed with cancer has always been taken as a death sentence by a majority of the population. This can partly be contributed by the fact that most people do not understand clearly what cancer is. The way most reporters and some journalist have reviewed information relating to prostate cancer has been hazardous. Proper cancer treatment, especially prostate cancer in men is possible as reviewed in this article. The article is a citation from the referenced materials and sources in which